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KMID : 1149220040120020119
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Korean Journal of Oriental Medical Prescription
2004 Volume.12 No. 2 p.119 ~ p.137
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The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in Colon-26
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Shin Min-Kyu
Kim Bong-Suk
Oh Jung-Han
Lim Hee-Yong
Kim Dong-Woo
Choi Bin-Hye
Kim Sang-Chan
Byun Joon-Seok
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Abstract
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In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to Colon-26 cell lines. Soonkiwhajungtang has only mimic direct anti-tumor effect against to Colon-26 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Soonkiwhajungtang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubidn and Soonkiwhajungtang extracts.
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KEYWORD
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Soonkiwhajungtang, doxorubicin, anti-tumor effect, Colon-26
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